Can I use a remote SMTP server with CDONTS.NewMail?

CDONTS.NewMail only supports local smtp servers, so you can't set up a remote server to handle your mail from this object. If you are unable or unwilling to configure the web server to support outgoing SMTP mail, you will need to use another product (you're going to have to migrate from CDONTS anyway, since it has been deprecated and no longer ships with Windows XP or Windows Server 2003). In Windows 2000 and above, you can use CDO.Message as follows: 
 

<!--       METADATA       TYPE="typelib"       UUID="CD000000-8B95-11D1-82DB-00C04FB1625D"       NAME="CDO for Windows 2000 Library"   -->   <%       Set cdoConfig = CreateObject("CDO.Configuration")         With cdoConfig.Fields           .Item(cdoSendUsingMethod) = cdoSendUsingPort           .Item(cdoSMTPServer) = "<enter_mail.server_here>"           .Update       End With         Set cdoMessage = CreateObject("CDO.Message")         With cdoMessage           Set .Configuration = cdoConfig           .From = "from@me.com"           .To = "to@me.com"           .Subject = "Sample CDO Message"           .TextBody = "This is a test for CDO.message"           .Send       End With         Set cdoMessage = Nothing       Set cdoConfig = Nothing   %>

 
See Article #2026 for several more CDO.Message code samples, techniques and troubleshooting information. 
 
If you don't have access to CDO.Message (e.g. running NT 4.0), see Article #2119 for a list of 3rd party COM objects that you can use instead. Most 3rd party mailing components support remote SMTP servers.